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The mechanisms observed in controlled laboratory settings may not fully translate to real-world clinical outcomes, and the durability of any effect remains uncertain
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In HFrEF, both the FIGHT [12] and LIVE [13] trials with liraglutide were neutral, showing no improvements in mortality, hospitalizations, ventricular function, or biomarkers, with LIVE additionally reporting increased heart rate and more cardiac adverse events in a small, heterogeneous population
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